Publications
Caruso Lab publications
BDNF Mitigates Early Oxidative Stress and Promotes Release of Neuroprotective Mitochondria from Striatal Astrocytes of zQ175 Huntington's disease mice
Couselo FL, Saba J, Friser Frederiksen M, Palmieri M, Romero AC, Bigi MM, Carniglia L, Durand D, Lasaga M, Caruso.
J Neurochemistry 2025 Oct;169(10):e70276.
doi: 10.1111/jnc.70276.​
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An extensive review about the role of astrocytes in neurodegeneration and neuroprotection.
The Essential Role of Astrocytes in Neurodegeneration and Neuroprotection
Couselo FL, Saba J, Carniglia L, Durand D, Lasaga M, Caruso.
CNS Neurol Disord Drug Targets 2023 october; online ahead of print.
doi: 10.2174/0118715273269881231012062255.
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An extensive review about the role of astrocytes in neurodegeneration and neuroprotection.
Neuroinflammation in Huntington's Disease: A Starring Role for Astrocyte and Microglia
Saba J, Couselo FL, Bruno J, Carniglia L, Durand D, Lasaga M, Caruso.
C.Curr Neuropharmacol. 2022;20(6):1116-1143.
doi: 10.2174/1570159X19666211201094608.
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An extensive review about the role of astrocytes and microglia in HD neuroinflammation.
Astrocytes from cortex and striatum show differential responses to mitochondrial toxin and BDNF: implications for protection of striatal neurons expressing mutant huntingtin
Saba J, López Couselo F, Turati J, Carniglia L, Durand D, de Laurentiis A, Lasaga M, Caruso C. J Neuroinflammation. 2020 Oct 6;17(1):290.
doi: 10.1186/s12974-020-01965-4.
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This work describes BDNF-treated striatal astrocytes protective effect on neurons expressing mutant Huntingtin.
Melanocortin 4 receptor activation protects striatal neurons and glial cells from 3-nitropropionic acid toxicity
Saba J, Carniglia L, Ramírez D, Turati J, Imsen M, Durand D, Lasaga M, Caruso C
Mol Cell Neurosci. 2019 Jan;94:41-51.
doi: 10.1016/j.mcn.2018.12.002.
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This paper describes the effect of melanocortin 4 receptor activation in the toxicity induced by 3-nitropropionic acid.
​Astrocyte truncated tropomyosin receptor kinase B mediates brain-derived neurotrophic factor anti-apoptotic effect leading to neuroprotection
Saba J, Turati J, Ramírez D, Carniglia L, Durand D, Lasaga M, Caruso C.
J Neurochem. 2018 Sep;146(6):686-702.
doi: 10.1111/jnc.14476.
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This work describes the protective effect of BDNF on astrocytes against serum deprivation and 3-nitropropionic acid.