Research topics

We investigate mechanism of neurodegeneration and neuroprotection using mice and cellular models. We perform molecular and behavioral analysis.

Mechanism of neurodegeneration and neuroprotection by glial cells

Our lab studies pathogenic and protective mechanisms in neurodegeneración, focusing on glial cells such as astrocytes and microglia in cellular and animal models of Huntington’s disease (HD). Our ultimate goal is to find new therapeutic targets that may become treatments for HD.

Mechanism of neurodegeneration
HMGB1

Mechanisms of neurodegeneration include oxidative stress, neuroinflammation, transcriptional dysregulation, defective DNA repair, and somatic instability. We study the role of high mobility group 1 (HMGB1) a singular protein involved in all the mechanism mentioned.

Mutant Huntingtin
interactions

Mutant Huntingtin (mHTT) is a scaffold protein that can interact with other proteins. We study the interaction of mHTT with nuclear proteins that affect neuronal survival in HD.

Mechanisms of neurodegeneration and neuroprotection by glial cells

We investigate how glial cells such as astrocytes and microglia participate in neurodegenerative and neuroprotective processes in Huntington's Disease

Research

Our lab studies pathogenic and protective mechanisms in neurodegeneración, focusing on glial cells such as astrocytes and microglia in cellular and animal models of Huntington’s disease (HD). Our ultimate goal is to find new therapeutic targets that may become treatments for HD.

Publications

BDNF Mitigates Early Oxidative Stress and Promotes Release of Neuroprotective Mitochondria from Striatal Astrocytes of zQ175 Huntington's disease mice

J Neurochemistry 2025 Oct;169(10):e70276.

doi: 10.1111/jnc.70276